Lipopolysaccharide suppresses IgE-mast cell-mediated reactions.
N WangM McKellA DangA YamaniL WaggonerS VanoniT NoahD WuA KordowskiJ KöhlK HoebeS DivanovicSimon Patrick HoganPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
Collectively, these studies suggest that LPS-induced IL-10 promotes the down-regulation of MC surface FcεRI expression and leads to desensitization of mice to IgE-mediated reactions. These studies indicate that targeting of the LPS-TLR-4-IL-10 pathway may be used as a therapeutic approach to prevent adverse IgE-mediated reactions.