NOTCH gene alterations in metastatic colorectal cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN).

Takeshi KajiwaraTomohiro NishinaAkio NakasyaNatsumi YamashitaRiu YamashitaYoshiaki NakamuraManabu ShiozawaSatoshi YukiHiroya TaniguchiHiroki HaraTakashi OhtaTaito EsakiEiji ShinozakiAtsuo TakashimaToshikazu MoriwakiTadamichi DendaKoushiro OhtsuboYu SunakawaYosuke HoritaHisato KawakamiTakeshi KatoTaroh SatohKoji AndoTomonori MizutaniHisateru YasuiMasahiro GotoHiroyuki OkuyamaKentaro YamazakiTakayuki YoshinoIchinosuke Hyodo

Published in: Journal of cancer research and clinical oncology (2022)

NOTCH genes are unlikely to harbor driver mutations and amplifications in patients with metastatic CRC. NOTCH3 variant should be further investigated as a favorable prognostic marker.

Keyphrases

metastatic colorectal cancer
genome wide
cell proliferation
papillary thyroid
genome wide identification
quality improvement
copy number
dna methylation
high throughput
cross sectional
genome wide analysis
single cell