Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine.

Daniel C MoreiraSujatha VenkataramanApurva SubramanianJohn DesistoIlango BalakrishnanEric PrinceAngela PierceAndrea GriesingerAdam GreenCharles G EberhardtNicholas K ForemanRajeev Vibhakar

Published in: Journal of neuro-oncology (2020)

Our results identified a potent new synergistic treatment combination for MYC-driven medulloblastoma that warrants exploration in early phase clinical trials.

Keyphrases

clinical trial
transcription factor
cancer therapy
randomized controlled trial
stress induced
phase ii
rectal cancer
replacement therapy
heat stress