Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial.
Sadaf Oliai AraghiJessica Christina Kiefte-de JongSuzanne C van DijkKarin M A SwartHanneke W van LaarhovenNatasja M van SchoorLisette C P G M de GrootValery LemmensBruno H StrickerAndre G UitterlindenNathalie van der VeldePublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2018)
Our findings suggest that folic acid and vitamin B12 supplementation may increase the risk of colorectal cancer. Further confirmation in larger studies and in meta-analyses combining both folic acid and vitamin B12 are needed to evaluate whether folic acid and vitamin B12 supplementation should be limited to patients with a known indication, such as a proven deficiency.