Wee1 kinase inhibitor adavosertib with radiation in newly diagnosed diffuse intrinsic pontine glioma: A Children's Oncology Group phase I consortium study.
Romain MuellerTabitha CooneyXiaodong YangSharmistha PalRalph ErmoianAmar GajjarXiaowei LiuKomal PremCharles G MinardJoel M ReidMarvin NelsonDaphne A Haas-KoganElizabeth FoxBrenda J WeigelPublished in: Neuro-oncology advances (2022)
Adavosertib in combination with CRT is well tolerated in children with newly diagnosed DIPG, however, compared to historical controls, did not improve OS. These results can inform future trial design in children with high-risk cancer.