Evaluating H3F3A K27M and G34R/V somatic mutations in a cohort of pediatric brain tumors of different and rare histologies.

Vinicius Fernandes OliveiraGraziella Ribeiro De SousaAntonio Carlos Dos SantosFabiano Pinto SaggioroHelio Rubens MachadoRicardo Santos de OliveiraLuiz Gonzaga ToneElvis Terci Valera

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)

Our investigation reinforces the low frequency of H3F3A somatic mutations outside the HGG setting. Interestingly, an atypical focal brainstem glioma carrying H3F3A K27M mutation that showed protracted clinical course with late-onset tumor progression was identified.

Keyphrases

late onset
early onset
copy number
poor prognosis
dna methylation