Covid-19 in cystic fibrosis patients compared to the general population: Severity and virus-host cell interactions.
Fabiana CicirielloFrancesco PanarielloPaola MedinoArianna BiffiFederico AlghisiChiara RosazzaPatrizia AnnunziataValentina BouchèAntonio GrimaldiDaniela GuidoneArianna VenturiniGianfranco AlicandroMassimo OggioniPellegrino CerinoGiulia PaiolaAndrea GramegnaAlessandro FiocchiAlessandra BanderaVincenzina LucidiDavide CacchiarelliLuis J V GaliettaCarla ColomboPublished in: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2024)
COVID-19 does not seem to be more severe in CF, possibly due to factors intrinsic to this population: the lower expression of ribosomal genes may downregulate the protein translation machinery, thus creating an unfavorable environment for viral replication.
Keyphrases
- cystic fibrosis
- sars cov
- coronavirus disease
- end stage renal disease
- ejection fraction
- chronic kidney disease
- poor prognosis
- single cell
- peritoneal dialysis
- binding protein
- respiratory syndrome coronavirus
- stem cells
- genome wide
- early onset
- small molecule
- patient reported
- protein protein
- air pollution
- transcription factor
- drug induced