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Genomic Mapping of Epidermal Growth Factor Receptor and Mesenchymal-Epithelial Transition-Up-Regulated Tumors Identifies Novel Therapeutic Opportunities.

Lucía Paniagua-HerranzBernard DogerCristina Díaz-TejeiroAdrian SanvicenteCristina Nieto-JiménezVictor MorenoPedro Pérez SeguraGyorffy BalazsEmiliano CalvoAlberto Ocaña
Published in: Cancers (2023)
The authors identified tumor types where EGFR and MET were highly expressed and correlated with a high expression of PD-L1, opening the door for the future combination of bi-specific EGFR/MET antibodies with anti-PD(L)1 inhibitors.
Keyphrases
  • epidermal growth factor receptor
  • tyrosine kinase
  • advanced non small cell lung cancer
  • poor prognosis
  • stem cells
  • high resolution
  • bone marrow
  • current status
  • transcription factor
  • copy number