Problem-solving therapy-induced amygdala engagement mediates lifestyle behavior change in obesity with comorbid depression: a randomized proof-of-mechanism trial.
Nan LvWesley K LeffertsLan XiaoAndrea N Goldstein-PiekarskiJoseph WielgoszPhilip W LavoriJanine M SimmonsJoshua M SmythPatrick StetzElizabeth M VendittiMegan A LewisLisa G RosasMark B SnowdenOlusola A AjiloreTrisha SuppesLeanne M WilliamsJun MaPublished in: The American journal of clinical nutrition (2021)
Short-term changes in the negative affect circuit engaged by threat stimuli following PST for depression mediated longer-term changes in physical activity. This trial was registered at www.clinicaltrials.gov as NCT02246413 (https://clinicaltrials.gov/ct2/show/NCT02246413).
Keyphrases
- physical activity
- metabolic syndrome
- phase iii
- study protocol
- sleep quality
- depressive symptoms
- weight loss
- phase ii
- clinical trial
- insulin resistance
- type diabetes
- computed tomography
- high glucose
- functional connectivity
- preterm infants
- diabetic rats
- social media
- body mass index
- randomized controlled trial
- weight gain
- image quality
- open label
- contrast enhanced
- oxidative stress
- magnetic resonance
- resting state
- positron emission tomography
- endothelial cells
- cell therapy
- mesenchymal stem cells
- gestational age
- stress induced
- preterm birth
- pet ct
- temporal lobe epilepsy