APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.

Sarah NaguibEileen Ruth TorresChloe Lopez-LeeLi FanMaitreyee BhagwatKendra NormanSe-In LeeJingjie ZhuPearly YeMan Ying WongTark PatelSue-Ann MokWenjie LuoSubhash C SinhaMingrui ZhaoShiaoching GongLi Gan

Published in: bioRxiv : the preprint server for biology (2024)

The R136S mutation on APOE3 enhances resistance to tau-related disease processes by downregulating the cGAS-STING-IFN signaling pathway.

Keyphrases

signaling pathway
cognitive decline
dendritic cells
immune response
high fat diet
cerebrospinal fluid
pi k akt
climate change
epithelial mesenchymal transition
social support
adipose tissue
mild cognitive impairment
depressive symptoms
oxidative stress
skeletal muscle