Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3.
Jayashree ChandrasekaranEmilien PetitYoung Woo ParkSophie Tezenas du MontcelJames M JoersDinesh K DeelchandMichal PovažanGuita BananRomain ValabreguePhilipp EhsesJennifer FaberPierrick CoupéChiadi U OnyikePeter B BarkerJeremy D SchmahmannEva-Maria RataiSub H SubramonyThomas H MareciKhalaf O BusharaHenry PaulsonAlexandra DurrThomas KlockgetherTetsuo AshizawaChristophe LengletGülin Öznull nullPublished in: Annals of neurology (2022)
Changes in cerebellar afferent and efferent pathways underlie the earliest symptoms of both SCAs. MR metrics collected with a harmonized advanced protocol in the multisite trial setting allow detection of disease effects in individuals before ataxia onset with potential clinical trial utility for subject stratification. ANN NEUROL 2022.