Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression.
Miriam RatliffKianush Karimian-JaziDirk C HoffmannLaurèl RauschenbachMatthias SimonLing HaiHenriette MandelbaumMarc C SchubertTobias KesslerStefanie UhligDaniel Dominguez AzorinErik JungMatthias OsswaldGergely SoleckiMáté E MarosVarun VenkataramaniMartin GlasNima EtminanBjörn SchefflerWolfgang WickFrank WinklerPublished in: Neuro-oncology (2023)
The detection of glioblastoma cells that harbor both particularly high proliferative and invasive capabilities during brain tumor progression provides valuable insights into the interrelatedness of proliferation and migration - two central traits of malignancy in glioma. This contributes to our understanding how the brain is efficiently colonized in this disease.