Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment.
Javier JarazoKyriaki BarmpaJennifer ModamioCláudia SaraivaSonia Sabate-SolerIsabel RosetyAnne GriesbeckFlorian SkwirbliesGaia ZaffaroniLisa M SmitsJihui SuJonathan Arias-FuenzalidaJonas WalterGemma Gomez-GiroAnna S MonzelXiaobing QingArmelle VitaliGerald CrucianiIbrahim BoussaadFrancesco BrunelliChristian JaegerAleksandar RakovicWen LiLin YuanEmanuel BergerGiuseppe ArenaSilvia BologninRonny SchmidtChristoph SchröderPaul M A AntonyChristine KleinRejko KrügerPhilip SeiblerJens Christian SchwambornPublished in: Movement disorders : official journal of the Movement Disorder Society (2021)
We show that treatment with a repurposed compound is sufficient for restoring the impaired dopaminergic differentiation of PD patient-derived cells. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.