A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants.

Shaofang LiLang LiuWenxian SunXueping ZhouHuanbin Zhou

Published in: Genome biology (2022)

Our findings that Cas proteins, TadA variants, temporal expression of ABEs, and expression levels of ABEs contribute to ABE specificity in rice provide insight into the specificity of ABEs and suggest alternative ways to increase ABE specificity besides engineering TadA variants.

Keyphrases

poor prognosis
copy number
single cell
genome wide
structural basis
gene expression
crispr cas
rna seq
long non coding rna