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Intracranial electroencephalographic biomarker predicts effective responsive neurostimulation for epilepsy prior to treatment.

Brittany H ScheidJohn M BernabeiAnkit N KhambhatiSofia MouchtarisJay JeschkeDanielle S BassettDanielle A BeckerKathryn A DavisTimothy LucasWerner DoyleEdward F ChangDaniel FriedmanVikram R RaoBrian Litt
Published in: Epilepsia (2022)
This study provides a proof-of-concept roadmap for collaborative biomarker evaluation in federated data, where practical considerations impede full data sharing across centers. Our results suggest that network synchronizability can help predict therapeutic response to RNS therapy. With further validation, this biomarker could facilitate patient selection and help avert a costly, invasive intervention in patients who are unlikely to benefit.
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