BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to PARP Inhibitors and Cisplatin.

Shino EndoYuki Yoshino Matsuyuki Shirota Gou Watanabe Natsuko Chiba

Published in: Cancer research communications (2021)

ASHRA could evaluate HR activity in cells and predict the sensitivity to PARP inhibitors. High expression level of ATF1 may predict the resistance of BRCAness tumors with alterations of non-BRCA1 HR factors to PARP inhibitors and platinum agents.

Keyphrases

dna damage
dna repair
induced apoptosis
endoplasmic reticulum stress
transcription factor
poor prognosis
oxidative stress
binding protein