Prognostic impact of peripheral blood neutrophil to lymphocyte ratio in advanced-stage pulmonary large cell neuroendocrine carcinoma and its association with the immune-related tumour microenvironment.

Masayuki ShirasawaTatsuya YoshidaHidehito HorinouchiShigehisa KitanoSayaka ArakawaYuji MatsumotoYuki ShinnoYusuke OkumaYasushi GotoShintaro KandaReiko WatanabeNoboru YamamotoShun-Ichi WatanabeYuichiro OheNoriko Motoi

Published in: British journal of cancer (2020)

A high NLR was associated with a poor prognosis in advanced LCNEC patients. Our study revealed that the NLR can reflect the TME, at least in part, suggesting that the NLR plays an important role not only as a clinical outcome predictor but also as a tumour immune status indicator.

Keyphrases

poor prognosis
peripheral blood
long non coding rna
end stage renal disease
single cell
newly diagnosed
chronic kidney disease
ejection fraction
pulmonary hypertension
prognostic factors
peritoneal dialysis
cell therapy
drug induced