Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9.

Tao GuoGuo-Qiao ChenXu-Fan LiMeng WangKun-Ming LiuXiao-Ying YangSi-Cheng LiuYi-Li FengPeng-Yuan LiuHui LinAn-Yong Xie

Published in: Genome medicine (2023)

Small eccDNAs carrying TSG mutations may serve as an important source supporting intratumor heterogeneity and tumor evolution in mouse liver cancer induced by multiplexed CRISPR/Cas9.

Keyphrases

crispr cas
single cell
genome editing
circulating tumor
cell free
single molecule
cancer therapy
drug delivery