Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type-Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney.

Samvid Kurlekar Joana Darc Carola Correia Lima Ran Li Olivia Lombardi Norma Masson Ayslan B Barros Virginia Pontecorvi David R Mole Christopher W Pugh Peter J Ratcliffe Peter J Ratcliffe

Published in: Cancer research (2024)

Single-cell analysis of heterogeneous and dynamic responses to Vhl inactivation in the kidney suggests that early events shape the cell type specificity of oncogenesis, providing a focus for mechanistic understanding and therapeutic targeting.

Keyphrases

single cell
rna seq
high throughput
cancer therapy
stem cells
gene expression
cell therapy
genome wide
structural basis