Login / Signup

Divergent On-DNA Transformations from DNA-Linked Piperidones.

Xing LingWeiwei LuLin MiaoLisa A MarcaurelleXuan WangYun DingXiaojie Lu
Published in: The Journal of organic chemistry (2021)
A group of highly efficient and divergent transformations for constructing multiple DNA-linked chemotypes based on a piperidone core were successfully developed. We reported the first procedure for the synthesis of a DNA-conjugated piperidine intermediate under basic conditions. Subsequently, this substructure was subjected to additional reactions to generate several privileged scaffolds, including 4-aminopiperidine, fused [1,2,4]triazolo[1,5-a]pyrimidine, and a quinoline derivative. These transformations paved the way for constructing focused scaffold-based DNA-encoded libraries with druglike properties.
Keyphrases
  • circulating tumor
  • cell free
  • highly efficient
  • single molecule
  • nucleic acid
  • circulating tumor cells
  • photodynamic therapy
  • tissue engineering
  • minimally invasive
  • molecular docking