Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence.
Abu SufianDebojit BhattacherjeePallavi BarmanAbhay SrivastavaRajkumar P ThummerKrishna Pada BhabakPublished in: Chemical communications (Cambridge, England) (2022)
Reactive oxygen species (ROS)-responsive near infrared (NIR) fluorogenic prodrug DCI-ROS is developed for the self-immolative release of diclofenac (DCF) with turn-on fluorescence. The non-toxic prodrug exhibited turn-on red fluorescence with endogenous ROS in cancer cells and inhibited COX-2 expression in the inflammation-induced macrophage cells. The prodrug strategy thus would be helpful for the controlled fluorogenic delivery of DCF for inflammatory diseases.
Keyphrases
- drug release
- reactive oxygen species
- cancer therapy
- drug delivery
- fluorescent probe
- single molecule
- living cells
- sensitive detection
- cell death
- dna damage
- oxidative stress
- energy transfer
- induced apoptosis
- anti inflammatory
- cell cycle arrest
- poor prognosis
- diabetic rats
- adipose tissue
- high glucose
- emergency department
- quantum dots
- cell proliferation
- endoplasmic reticulum stress
- photodynamic therapy
- electronic health record