Plasma neurofilament light chain as a biomarker for fatal familial insomnia.
Peter HermannSezgi CanaslanAnna Villar-PiquéTimothy BunckStefan GoebelFranc LlorensMatthias SchmitzInga ZerrPublished in: European journal of neurology (2022)
Plasma neurofilament light chain may be a valuable minimally invasive diagnostic biomarker for fatal familial insomnia after clinical onset. Most important, stage-related increase and association with disease duration indicate potential as a prognostic marker and as a surrogate marker in clinical trials.