Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.

Xiaoduan LiYi ZhangXinjing WangFeikai LinXi ChengZiliang WangXipeng Wang

Published in: Cell biology and toxicology (2021)

1. CTSLP8 was upregulated in the chemotherapy-resistant tumor tissues. 2. CTSLP8 promoted the proliferation and cisplatin resistance in the OC cells. 3. CTSLP8 promoted glycolysis by facilitating the binding of PKM2 to the promoter region of c-Myc. 4. Inhibition of CTSLP8 or the combination of c-Myc inhibitors with cisplatin were potential therapeutic strategies for chemotherapy-resistant of OC.

Keyphrases

long non coding rna
poor prognosis
locally advanced
induced apoptosis
signaling pathway
gene expression
dna methylation
transcription factor
binding protein
oxidative stress
radiation therapy
rectal cancer
risk assessment
dna binding
cell proliferation