Efficacy of Co-Crystal of Tramadol-Celecoxib (CTC) in Patients with Acute Moderate-to-Severe Pain: A Pooled Analysis of Data from Two Phase 3 Randomized Clinical Trials.

Richard Langford Eugene R Viscusi Adelaida Morte Jesús Cebrecos Mariano Sust José María Giménez-Arnau Oscar A deLeon-Casasola

Published in: Drugs in R&D (2024)

This pooled analysis reinforces the efficacy profile of CTC versus tramadol and, given that CTC permits lower daily tramadol dosing and thereby reduces unnecessary opioid use, this highlights its improved benefit/risk profile and its potential for the management of moderate-to-severe pain.

Keyphrases

circulating tumor cells
chronic pain
pain management
neuropathic pain
circulating tumor
high intensity
early onset
postoperative pain
physical activity
electronic health record
randomized controlled trial
spinal cord
machine learning