Identification of Differentially Expressed Genes and Elucidation of Pathophysiological Relevance of ABCA1 in HaCaT Cells Induced by PM2.5.
Fen PengChen-Hong XueXiao-Jing YangJing-Yi HuangZhou ChenJian-Zhong ZhangPublished in: Bioinorganic chemistry and applications (2021)
Our results showed that PM2.5 could potentially regulate cell apoptosis and cell cycle arrest via ABCA1-, END1-, ID1-, and CLDN1-mediated pathways in human HaCaT cells, which laid a good foundation for follow-up drug intervention and drug development against skin damage caused by PM2.5 exposure.
Keyphrases
- cell cycle arrest
- cell death
- pi k akt
- particulate matter
- induced apoptosis
- air pollution
- polycyclic aromatic hydrocarbons
- randomized controlled trial
- endothelial cells
- heavy metals
- signaling pathway
- oxidative stress
- water soluble
- bioinformatics analysis
- transcription factor
- genome wide
- risk assessment
- electronic health record
- drug induced
- adverse drug
- wound healing