ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein.
Gillian BonviciniStina SyvänenKen G AnderssonMerja Haaparanta-SolinFrancisco López-PicónDag SehlinPublished in: Translational neurodegeneration (2022)
Affinity to TfR affects how efficiently a TfR-targeting bispecific fusion protein will cross the BBB, such that the higher-affinity bispecific fusion protein crossed the BBB more efficiently. Furthermore, bispecific immunoPET imaging of brain Aβ pathology using TfR-mediated transport provides good imaging contrast between TgF344-AD and WT rats, suggesting that this immunoPET strategy has the potential to be translated to higher species.
Keyphrases
- high resolution
- blood brain barrier
- white matter
- resting state
- magnetic resonance
- magnetic resonance imaging
- brain injury
- mass spectrometry
- functional connectivity
- multiple sclerosis
- risk assessment
- transforming growth factor
- computed tomography
- cancer therapy
- cerebral ischemia
- fluorescence imaging
- subarachnoid hemorrhage