Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes.

Abdulelah S AlshawliHeiko WurdakIan C WoodJohn Edward Ladbury

Published in: Molecular genetics & genomic medicine (2020)

The findings of this study indicate that REST is not essential for sustaining the proliferation/viability of the Daoy cells. It also revealed that the anti-proliferative effect of HDACi is independent of REST expression.

Keyphrases

histone deacetylase
cell death
cell cycle arrest
induced apoptosis
poor prognosis
signaling pathway
endoplasmic reticulum stress
binding protein