Comparison of Approaches for Stroke Prophylaxis in Patients with Non-Valvular Atrial Fibrillation: Network Meta-Analyses of Randomized Controlled Trials.

Navkaranbir S BajajRajat KalraNirav PatelTaimoor HashimHemant GodaraSameer AtherGarima AroraTilak PasalaThomas T WhitfieldDavid C McGiffinMustafa I AhmedSteven G LloydNita A LimdiPankaj Arora

Published in: PloS one (2016)

Dose-adjusted vitamin K antagonists, novel oral anticoagulants, and the WATCHMAN left atrial appendage closure devices are equally efficacious for ischemic stroke prevention but these treatments have different safety profiles. More randomized controlled trials are needed to directly compare these strategies.

Keyphrases

atrial fibrillation
left atrial appendage
oral anticoagulants
meta analyses
catheter ablation
randomized controlled trial
systematic review
left atrial
direct oral anticoagulants
heart failure
percutaneous coronary intervention
clinical evaluation
network analysis
brain injury