Reduced PU.1 Expression Collaborates with Tet2 Loss to Trigger Myeloid Leukemogenesis.

Published in: Blood cancer discovery (2022)

The leukemic transformation of hematopoietic stem and progenitor cells in the setting of Tet2 deficiency is driven by PU.1 gene network loss through complementary reduction in PU.1 expression and hypermethylation of ETS loci at the enhancers of PU.1 target genes. See related article by Aivalioti et al., p. 444 (6).

Keyphrases

poor prognosis
genome wide
acute myeloid leukemia
genome wide identification
transcription factor
binding protein
bone marrow
long non coding rna
copy number
immune response
replacement therapy
genome wide association study