lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs.
Yu YuanYi HeBinaya WastiWentao DuanJingsi JiaZhifeng ChenXu-Dong XiangQingping ZengPublished in: Oxidative medicine and cellular longevity (2023)
lncRNA CRNDE expression downregulation led to reduced inflammation and reduced lung damage in mice with induced asthma, it inhibited the EMTs of lung epithelial cells via the miR-29a-3p/MCL-1 pathway, and it reduced the levels of Th17/IL-17A cells to reduce asthma signs.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- epithelial mesenchymal transition
- oxidative stress
- allergic rhinitis
- induced apoptosis
- signaling pathway
- long non coding rna
- poor prognosis
- diabetic rats
- cell proliferation
- transforming growth factor
- high glucose
- type diabetes
- long noncoding rna
- binding protein
- drug induced
- endothelial cells
- insulin resistance
- endoplasmic reticulum stress
- cell death