Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent.
Hannah PainterSasha E LarsenBrittany D WilliamsHazem F M AbdelaalSusan L BaldwinHelen A FletcherAndrew-Fiore GartlandRhea N ColerPublished in: bioRxiv : the preprint server for biology (2024)
Human-derived biosignatures of tuberculosis disease progression were evaluated for their predictive fidelity across preclinical species and derived tissues using available public data sets.
Keyphrases
- endothelial cells
- mycobacterium tuberculosis
- induced pluripotent stem cells
- healthcare
- pluripotent stem cells
- hiv aids
- pulmonary tuberculosis
- cell therapy
- adverse drug
- mental health
- stem cells
- electronic health record
- big data
- bone marrow
- emergency department
- hiv infected
- mesenchymal stem cells
- hepatitis c virus
- human immunodeficiency virus
- data analysis