Rare correlation of somatic PRKACA mutations with pregnancy-associated aldosterone- and cortisol-producing adenomas: a case report and literature review.

Jianfan LinYufei LiZhenxing HuangYingli ZhuLi LiHaiyan YangXinghuan LiangYingfen QinJia ZhouJing XianDeyun LiuDecheng LuZuo-Jie Luo

Published in: BMC endocrine disorders (2024)

Somatic mutations in PRKACA may correlate with the upregulation of LHCGR, which synergistically drives the accelerated growth of co-secretion tumors during pregnancy, thereby exacerbating disease progression.

Keyphrases

copy number
poor prognosis
cell proliferation
preterm birth
angiotensin ii
signaling pathway
pregnancy outcomes