Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane.
Saeed FarzamfarMajid SalehiArian EhteramiMahdi Naseri-NosarAhmad VaezAmir Hassan ZarnaniHamed SahrapeymaMohammad-Reza ShokriMehdi AleahmadPublished in: Biomedical engineering letters (2018)
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 104 cells/cm2 and implanted onto a rat's 1.50 × 1.50 cm2 full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
Keyphrases
- wound healing
- stem cells
- endothelial cells
- cell therapy
- induced pluripotent stem cells
- surgical site infection
- induced apoptosis
- extracellular matrix
- pluripotent stem cells
- single cell
- soft tissue
- cell cycle arrest
- endoplasmic reticulum stress
- tissue engineering
- machine learning
- signaling pathway
- cell death
- climate change
- deep learning
- combination therapy