Risk of Advanced Neoplasia in First-Degree Relatives with Colorectal Cancer: A Large Multicenter Cross-Sectional Study.

Enrique QuinteroMarta CarrilloMaria-Liz LeozJoaquín Cubiella FernándezCarla GargalloAngel LanasLuis BujandaAntonio Z Gimeno-GarcíaManuel Hernández-GuerraDavid Nicolás-PérezInmaculada Alonso-AbreuJuan Diego MorillasFrancesc BalaguerAlfonso Murielnull null

Published in: PLoS medicine (2016)

Individuals having two FDR with colorectal cancer showed an increased risk of advanced neoplasia compared to those with average-risk for colorectal cancer. Men had over 2-fold higher risk of advanced neoplasia than women, independent of family history. These data suggest that screening colonoscopy guidelines should be revised in the familial-risk population.

Keyphrases

high grade
polycystic ovary syndrome
electronic health record

metabolic syndrome
big data
clinical trial

clinical practice
cross sectional
skeletal muscle

breast cancer risk
adipose tissue
pregnancy outcomes