The study of GSDMB in pathogenesis of psoriasis vulgaris.

Xiaojuan JiHuaqing ChenLing XieShiqi ChenShan HuangQi TanHuifang YangTao YangXiaoying YeZhaolin ZengChunlei WanLongnian Li

Published in: PloS one (2023)

The expression level of GSDMB in psoriasis vulgaris lesion tissue is lower than that of normal skin tissue. The down-regulation of GSDMB expression can inhibit cell proliferation and promote cell apoptosis. GSDMB may play a role in the pathogenesis of psoriasis by affecting the differentiation of keratinocytes and the function of T cells.

Keyphrases

cell proliferation
poor prognosis
binding protein
wound healing
cell cycle
pi k akt
signaling pathway