Urinary Vitamin D Binding Protein: A Marker of Kidney Tubular Dysfunction in Patients at Risk for Type 2 Diabetes.
Zhila Semnani-AzadWindy Z N WangDavid E C ColeLuke W JohnstonBetty Y L WongLei FuRavi RetnakaranStewart B HarrisAnthony J HanleyPublished in: Journal of the Endocrine Society (2024)
< .001). There was no significant association between uVDBP and eGFR at baseline. Adjusted longitudinal GEE models indicated that each SD increase both in baseline and longitudinal uVDBP:cr was significantly associated with higher ACR over 6 years (β = 30.67 and β = 32.91, respectively). Conversely, neither baseline nor longitudinal uVDBP:cr measures showed a significant association with changes in eGFR over time. These results suggest that loss of uVDBP:cr over time may be a useful marker for predicting renal tubular damage in individuals at risk for diabetes.
Keyphrases
- type diabetes
- small cell lung cancer
- end stage renal disease
- binding protein
- epidermal growth factor receptor
- cardiovascular disease
- glycemic control
- cross sectional
- tyrosine kinase
- oxidative stress
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- adipose tissue
- patient reported outcomes
- high glucose
- skeletal muscle