Mechanism-guided engineering of a minimal biological particle for genome editing.
Wayne NgoJulia T PeukesAlisha BaldwinZhiwei Wayne XueSidney HwangRobert R StickelsZhi LinAnsuman T SatpathyJames A WellsRandy SchekmanEva NogalesJennifer A DoudnaPublished in: bioRxiv : the preprint server for biology (2024)
Our results highlight the importance of understanding how virally-derived particles function to eliminate unnecessary viral proteins and create more efficacious and easier-to-produce delivery vehicles for therapeutic genome editing.
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