Clinical, contextual and hospital-level factors associated with escalation and de-escalation of empiric Gram-negative antibiotics among US inpatients.

Jonathan D Baghdadi Katherine E GoodmanLaurence S MagderEmily L HeilKimberly ClaeysJacqueline BorkAnthony D Harris

Published in: JAC-antimicrobial resistance (2023)

Empiric Gram-negative antibiotics are frequently de-escalated early in hospitalization, whereas escalation is infrequent. Changes are primarily driven by choice of empiric therapy and presence of infectious syndromes.

Keyphrases

gram negative
multidrug resistant
open label
urinary tract infection
healthcare
clinical trial
emergency department
acute care
stem cells
randomized controlled trial
study protocol
electronic health record
replacement therapy