A systematic literature review of the effects of immunoglobulin replacement therapy on the burden of secondary immunodeficiency diseases associated with hematological malignancies and stem cell transplants.

Clara Monleón BonetNathalie WaserKaren ChengSpiros TzivelekisJ David M EdgarSilvia Sánchez-Ramón

Published in: Expert review of clinical immunology (2020)

Overall, the findings show several beneficial effects of IGRT on clinical outcomes and quality of life; however, disparate definitions, infrequent reporting of statistical significance, and scarcity of clinical trial data after the 1990s present areas for further investigation. This paucity indicates an unmet need of current evidence to assess the benefits of IGRT in SID.

Keyphrases

replacement therapy
stem cells
clinical trial
smoking cessation
electronic health record
adverse drug
phase ii
big data
open label
study protocol
risk factors
phase iii
randomized controlled trial
emergency department
cell therapy
data analysis
machine learning
mesenchymal stem cells