Gabapentin affects the expression of inflammatory mediators on healthy gingival cells.
Valentina CandottoLuca ScapoliRosa Maria GaudioAldo Bruno GianniAlessandro BolzoniPierpaolo RaccoLauritano DorinaFrancesca CuraPublished in: International journal of immunopathology and pharmacology (2020)
Gabapentin is one of the most used drugs to treat postoperative pain with antihyperalgesic properties and has a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that the perioperative use of gabapentin reduces postoperative pain. In our study, fragments of gingival tissue of healthy volunteers were collected during operation. Gene expression of 29 genes was investigated in gingival fibroblasts cell culture treated with gabapentin, compared with untreated cells. Of the different chemokines and interleukins studied, only 10 were statistically significant (CCL1, CCR1, CCR4, CCR5, CCR6, ILI1A, ILI1B, IL5, IL6R, TNFSF10). The overexpression of these cytokines, obtained in many studies, leads us to think that gabapentin can interact and cause post-inflammatory gingival hyperplasia, but, probably, in our study the gabapentin has not the same effect, because we used gingival fibroblasts of healthy people.
Keyphrases
- postoperative pain
- neuropathic pain
- gene expression
- induced apoptosis
- dendritic cells
- regulatory t cells
- cell cycle arrest
- oxidative stress
- spinal cord injury
- poor prognosis
- dna methylation
- spinal cord
- patients undergoing
- cell proliferation
- cell death
- drug induced
- liver injury
- pi k akt
- binding protein
- atomic force microscopy
- genome wide analysis