Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells.

Xuelian CuiChao ZhangZhifang XuShuaibin WangXin LiErica Stringer-ReasorSejong BaeLeiping ZengDehua ZhaoRunhua LiuLei S QiLizhong Wang

Published in: Molecular cancer (2022)

The simultaneous activation and repression of the X-linked, endogenous FOXP3 and XIST from XCI offers a useful research tool and a potential therapeutic for female breast cancers.

Keyphrases

regulatory t cells
breast cancer cells
endothelial cells
crispr cas
genome editing
induced pluripotent stem cells
cancer therapy
immune response
drug delivery
young adults