Fraction dose escalation of hypofractionated radiotherapy with concurrent chemotherapy and subsequent consolidation immunotherapy in locally advanced non-small cell lung cancer: a phase 1 study.

Rui Zhou FangJie Liu HongMei Zhang DaQuan Wang PengXin Zhang Shiyang Zheng YiMei Liu Li Chen JinYu Guo YingYi Zou Yu-Ming Rong Hui Liu Bo Qiu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Utilizing the split-course hypo-RT and hypo-boost approach, a fraction dose of 5Gy to a total dose of 60Gy, combined with concurrent chemotherapy and subsequent cICI, was well-tolerated, and yielded promising ORR and survival outcomes.

Keyphrases

locally advanced
advanced non small cell lung cancer
radiation therapy
rectal cancer
squamous cell carcinoma
open label
epidermal growth factor receptor
early stage
randomized controlled trial
small cell lung cancer
radiation induced
chemotherapy induced
placebo controlled