Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Lina VandermeulenIvana GericLaura FumagalliMohamed KreirAshley LuAnnelies NonnemanJessie PremereurLeen WolfsRafaela PolicarpoNicola FattorelliAn De BondtIlse Van Den WyngaertBob AsselberghMark FiersBart De StrooperConstantin d'YdewalleRenzo Mancuso

Published in: Molecular neurodegeneration (2024)

This study is the first proof-of-concept that human microglial can be modulated using ASOs in a dose-dependent manner to manipulate microglia phenotypes and response to neurodegeneration in vivo.

Keyphrases

gene expression
endothelial cells
inflammatory response
neuropathic pain
induced pluripotent stem cells
lipopolysaccharide induced
pluripotent stem cells
dna methylation
lps induced
cognitive decline
spinal cord injury