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In vitro neurotoxicity testing: lessons from chemotherapy-induced peripheral neurotoxicity.

Olga TarasiukChiara InvernizziPaola Alberti
Published in: Expert opinion on drug metabolism & toxicology (2024)
CIPN is an ideal experimental setting to test axonal damage and, in general, peripheral nervous system mechanisms of disease and neuroprotection. Therefore, starting from robust preclinical data in this field, potentially, relevant biological rationale can be transferred to other human spontaneous diseases of the peripheral nervous system.
Keyphrases
  • chemotherapy induced
  • endothelial cells
  • spinal cord injury
  • oxidative stress
  • electronic health record
  • induced pluripotent stem cells
  • cell therapy
  • big data
  • pluripotent stem cells