Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol.
Peitao WuJee-Young MoonIyas DaghlasGiulianini FrancoBianca C PornealaAnke H Maitland-van der ZeeTom G RichardsonJonas L IsaksenGeorgy HindyJie YaoColleen M SitlaniLaura M RaffieldLisa R YanekMary F FeitosaRafael R C CuadratQibin QiM Arfan IkramChristina EllervikUlrika EricsonMark O GoodarziJennifer A BrodyLeslie LangeJosep Maria MercaderDhananjay VaidyaPing AnMatthias Bernd SchulzeLluis MasanaMohsen GhanbariMorten S OlesenJianwen CaiXiuqing GuoJames S FloydSusanne JägerMichael A ProvinceRita R KalyaniBruce M PsatyMarju Orho-MelanderPaul M RidkerJørgen K KantersAndre UitterlindenGeorge Davey SmithDipender GillRobert C KaplanMaryam KavousiSridharan RaghavanDaniel I ChasmanJerome I RotterJames B MeigsJose C FlorezJosée DupuisChing-Ti LiuRuth J F LoosPublished in: Diabetes care (2021)
These findings suggest that the diabetogenic effect attributed to lowering LDLc is partially mediated through increased BMI. Our results could help advance understanding of adipose tissue and lipids in type 2 diabetes pathophysiology and inform strategies to reduce diabetes risk among individuals taking LDLc-lowering medications.