Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Jingyu ZhanDong LinNathan W WatsonLothar EsserWai Kwan TangAlex ZhangXiufen LiuRaffit HassanAnne S GleinichAsif ShajahanParastoo AzadiIra H PastanDi XiaPublished in: Cancer research communications (2023)
The structures of full-length mesothelin and its complexes with antibodies reported here are the first to be determined experimentally, providing atomic models for structural organization of this protein and its interactions with antibodies. It offers insights into the function of mesothelin and guidance for further development of therapeutic antibodies.