Ira H Pastan (Ira Pastan, I Pastan)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 33

Top Topics

Monoclonal Antibody

Acute Lymphoblastic Leukemia

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Molecular cancer therapeutics

Science translational medicine

This page only lists publications with an associated author ORCID identifier.

Publications

X F Liu, M Onda, J Schlomer, Laura L Bassel, S Kozlov, C-H Tai, Q Zhou, Wenlong Liu, H-E Tsao, R Hassan, Mitchell Ho, Ira H Pastan
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
X F Liu, M Onda, J Schlomer, Laura L Bassel, S Kozlov, C-H Tai, Q Zhou, Wenlong Liu, H-E Tsao, R Hassan, Mitchell Ho, Ira H Pastan
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Anirban Chakraborty, Masanori Onda, Tara O'Shea, Junxia Wei, Xiufen Liu, Tapan K Bera, Ira H Pastan
A Bispecific Antibody That Targets the Membrane-Proximal Region of Mesothelin and Retains High Anticancer Activity in the Presence of Shed Mesothelin. Molecular cancer therapeutics (2024)
X F Liu, M Onda, J Schlomer, Laura L Bassel, S Kozlov, C-H Tai, Q Zhou, Wenlong Liu, H-E Tsao, R Hassan, Mitchell Ho, Ira H Pastan
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
X F Liu, M Onda, J Schlomer, Laura L Bassel, S Kozlov, C-H Tai, Q Zhou, Wenlong Liu, H-E Tsao, R Hassan, Mitchell Ho, Ira H Pastan
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
X F Liu, M Onda, J Schlomer, Laura L Bassel, S Kozlov, C-H Tai, Q Zhou, Wenlong Liu, H-E Tsao, R Hassan, Mitchell Ho, Ira H Pastan
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Anirban Chakraborty, Masanori Onda, Tara O'Shea, Junxia Wei, Xiufen Liu, Tapan K Bera, Ira H Pastan
A bispecific antibody that targets the membrane-proximal region of mesothelin and retains high anticancer activity in the presence of shed mesothelin. Molecular cancer therapeutics (2024)
X F Liu, M Onda, J Schlomer, Laura L Bassel, S Kozlov, C-H Tai, Q Zhou, Wenlong Liu, H-E Tsao, R Hassan, Mitchell Ho, Ira H Pastan
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Jingyu Zhan, Dong Lin, Nathan W Watson, Lothar Esser, Wai Kwan Tang, Alex Zhang, Xiufen Liu, Raffit Hassan, Anne S Gleinich, Asif Shajahan, Parastoo Azadi, Ira H Pastan, Di Xia
Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer research communications 3 (2) (2023)
Scott Parker, Charlotte McDowall, Luis Sanchez-Perez, Cristina Osorio, Patrick C Duncker, Aaron Briley, Adam M Swartz, James E Herndon, Yen-Rei A Yu, Roger E McLendon, Thomas F Tedder, Annick Desjardins, David M Ashley, Michael Dee Gunn, David S Enterline, David A Knorr, Ira H Pastan, Smita K Nair, Darell D Bigner, Vidyalakshmi Chandramohan
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models. Science translational medicine 15 (682) (2023)
Jingyu Zhan, Dong Lin, Nathan W Watson, Lothar Esser, Wai Kwan Tang, Alex Zhang, Xiufen Liu, Raffit Hassan, Anne S Gleinich, Asif Shajahan, Parastoo Azadi, Ira H Pastan, Di Xia
Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer research communications 3 (2) (2023)
Scott Parker, Charlotte McDowall, Luis Sanchez-Perez, Cristina Osorio, Patrick C Duncker, Aaron Briley, Adam M Swartz, James E Herndon, Yen-Rei A Yu, Roger E McLendon, Thomas F Tedder, Annick Desjardins, David M Ashley, Michael Dee Gunn, David S Enterline, David A Knorr, Ira H Pastan, Smita K Nair, Darell D Bigner, Vidyalakshmi Chandramohan
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models. Science translational medicine 15 (682) (2023)
Scott Parker, Charlotte McDowall, Luis Sanchez-Perez, Cristina Osorio, Patrick C Duncker, Aaron Briley, Adam M Swartz, James E Herndon, Yen-Rei A Yu, Roger E McLendon, Thomas F Tedder, Annick Desjardins, David M Ashley, Michael Dee Gunn, David S Enterline, David A Knorr, Ira H Pastan, Smita K Nair, Darell D Bigner, Vidyalakshmi Chandramohan
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models. Science translational medicine 15 (682) (2023)
Guannan Wang, Alok Kumar, Wanjun Ding, Preethi Korangath, Tapan Bera, Junxia Wei, Priya Pai, Kathleen Gabrielson, Ira H Pastan, Saraswati Sukumar
Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer-a preclinical study. Proceedings of the National Academy of Sciences of the United States of America 119 (24) (2022)
Jiajia Pan, Nan Li, Alex Renn, Hu Zhu, Lu Chen, Min Shen, Matthew D Hall, Min Qian, Ira H Pastan, Mitchell Ho
GPC1-Targeted Immunotoxins Inhibit Pancreatic Tumor Growth in Mice via Depletion of Short-lived GPC1 and Downregulation of Wnt Signaling. Molecular cancer therapeutics 21 (6) (2022)
Kazuyoshi Yamamoto, Masahiro Okabe, Keiko Tanaka, Takashi Yokoo, Ira H Pastan, Toshikazu Araoka, Kenji Osafune, Tomohiro Udagawa, Masahiro Koizumi, Taiji Matsusaka
Podocytes are lost from glomeruli before completing apoptosis. American journal of physiology. Renal physiology 323 (5) (2022)
Sakshi Tomar, Jingli Zhang, Manakamana Khanal, Jessica Hong, Abhilash Venugopalan, Qun Jiang, Manjistha Sengupta, Markku M Miettinen, Nan Li, Ira H Pastan, Mitchell Ho, Raffit Hassan
Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors. Molecular cancer therapeutics 21 (7) (2022)
Wenlong Liu, Chin-Hsien Tai, Xiufen Liu, Ira H Pastan
Anti-mesothelin immunotoxin induces mesothelioma eradication, anti-tumor immunity, and the development of tertiary lymphoid structures. Proceedings of the National Academy of Sciences of the United States of America 119 (48) (2022)
Xiufen Liu, Masanori Onda, Nathan Watson, Raffit Hassan, Mitchell Ho, Tapan K Bera, Junxia Wei, Anirban Chakraborty, Richard Beers, Qi Zhou, Asif Shajahan, Parastoo Azadi, Jingyu Zhan, Di Xia, Ira H Pastan
Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin. Proceedings of the National Academy of Sciences of the United States of America 119 (19) (2022)
Qun Jiang, Azam Ghafoor, Idrees Mian, Daniel Rathkey, Anish Thomas, Christine Alewine, Manjistha Sengupta, Mark A Ahlman, Jingli Zhang, Betsy Morrow, Seth M Steinberg, Ira H Pastan, Raffit Hassan
Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti-PD-1 antibody in patients with mesothelioma and mouse tumor models. Science translational medicine 12 (550) (2021)
Takahiro Nishio, Yukinori Koyama, Xiao Liu, Sara B Rosenthal, Gen Yamamoto, Hiroaki Fuji, Jacopo Baglieri, Na Li, Laura N Brenner, Keiko Iwaisako, Kojiro Taura, James S Hagood, Nicholas F LaRusso, Tapan K Bera, Ira H Pastan, David A Brenner, Tatiana Kisseleva
Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Proceedings of the National Academy of Sciences of the United States of America 118 (29) (2021)
Xui-Fen Liu, Junxia Wei, Qi Zhou, Bruce A Molitoris, Ruben Sandoval, Hisataka Kobayashi, Ryuhei Okada, Tadanobu Nagaya, Baktiar Karim, Donna Butcher, Ira H Pastan
Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine. Proceedings of the National Academy of Sciences of the United States of America 117 (11) (2020)
Robert J Kreitman, Ira H Pastan
Development of Recombinant Immunotoxins for Hairy Cell Leukemia. Biomolecules 10 (8) (2020)
Xiufen Liu, Alexander Chan, Chin-Hsien Tai, Thorkell Andresson, Ira H Pastan
Multiple proteases are involved in mesothelin shedding by cancer cells. Communications biology 3 (1) (2020)
Zoë Shancer, Xiu-Fen Liu, Satoshi Nagata, Qi Zhou, Tapan K Bera, Ira H Pastan
Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models. Proceedings of the National Academy of Sciences of the United States of America 116 (10) (2019)
Yohei Tsuchida, Jianyong Zhong, Tadashi Otsuka, Anna Dikalova, Ira H Pastan, G M Anantharamaiah, MacRae F Linton, Patricia G Yancey, T Alp Ikizler, Agnes B Fogo, Haichun Yang, Valentina Kon
Lipoprotein modulation of proteinuric renal injury. Laboratory investigation; a journal of technical methods and pathology 99 (8) (2019)
Zeliang Zheng, Ryuhei Okada, Hisataka Kobayashi, Tadanobu Nagaya, Junxia Wei, Qi Zhou, Fred Lee, Tapan K Bera, Yun Gao, William Kuhlman, Chin-Hsien Tai, Ira H Pastan
Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity. Molecular cancer therapeutics 19 (3) (2019)
Yasmin Leshem, Ira H Pastan
Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient's Bedside to Evaluation in Preclinical Models. Toxins 11 (1) (2019)
Takeshi Zoshima, Satoshi Hara, Masakazu Yamagishi, Ira H Pastan, Taiji Matsusaka, Mitsuhiro Kawano, Michio Nagata
Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits. Scientific reports 9 (1) (2019)
Masanori Onda, Kazuto Kobayashi, Ira H Pastan
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity. Proceedings of the National Academy of Sciences of the United States of America 116 (10) (2019)
Fabian Müller, Tyler Cunningham, Richard Beers, Tapan K Bera, Alan S Wayne, Ira H Pastan
Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia. Toxins 10 (5) (2018)
Yasmin Leshem, Emily M King, Ronit Mazor, Yoram Reiter, Ira H Pastan
SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors. Toxins 10 (11) (2018)
Emily M King, Ronit Mazor, Nicolas Çuburu, Ira H Pastan
Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin. Journal of immunology (Baltimore, Md. : 1950) 200 (6) (2018)