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Electrochemiluminescence platform for transcription factor diagnosis by using CRISPR-Cas12a trans-cleavage activity.

Zhenqiang FanYuedi DingBo YaoJiaying WangKai Zhang
Published in: Chemical communications (Cambridge, England) (2021)
Herein, we exploited the double-stranded DNA (dsDNA) binding property of transcription factor (TF), combined with the trans cleavage characteristic of CRISPR-Cas12a, for the detection of NF-κB p50.
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