Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling.
Degang SongXiaomin ChenNa ZhouYi YuanShuo GengCong ZhangZhe ZhaoXingran WangXinran BaoXifa LanXiang-Jian ZhangPublished in: Journal of translational medicine (2023)
LIPUS induced a neurorestorative stimulation against VaD may be through upregulation of the hippocampal Fndc5/irisin levels. Hippocampal Fndc5/irisin signaling might be a promising strategic target for VaD.
Keyphrases
- cerebral ischemia
- cognitive impairment
- subarachnoid hemorrhage
- temporal lobe epilepsy
- magnetic resonance imaging
- mild cognitive impairment
- cell proliferation
- drug induced
- blood brain barrier
- signaling pathway
- diabetic rats
- poor prognosis
- computed tomography
- oxidative stress
- metabolic syndrome
- adipose tissue
- skeletal muscle
- ultrasound guided