Silencing FUT4 Inhibits the Progression of Osteosarcoma through Activation of FOXO1.

Yang YangXiaodi YanYueYuan ChenJiajia LiuJianhua XueXiaoming ShengJun QinQiang XueXianchen Liu

Published in: Current pharmaceutical design (2024)

Osteosarcoma cells express more FUT4. The Wnt/β-catenin signaling pathway has a significant effect on osteosarcoma cell death, and inhibition of FUT4 expression may target FOXO1 activation to decrease osteosarcoma cells' ability to proliferate, invade, and migrate.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
pi k akt
transcription factor
stem cells
poor prognosis
cell proliferation
endoplasmic reticulum stress
oxidative stress