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Silencing FUT4 Inhibits the Progression of Osteosarcoma through Activation of FOXO1.

Yang YangXiaodi YanYueYuan ChenJiajia LiuJianhua XueXiaoming ShengJun QinQiang XueXianchen Liu
Published in: Current pharmaceutical design (2024)
Osteosarcoma cells express more FUT4. The Wnt/β-catenin signaling pathway has a significant effect on osteosarcoma cell death, and inhibition of FUT4 expression may target FOXO1 activation to decrease osteosarcoma cells' ability to proliferate, invade, and migrate.
Keyphrases
  • cell cycle arrest
  • cell death
  • induced apoptosis
  • pi k akt
  • transcription factor
  • stem cells
  • poor prognosis
  • cell proliferation
  • endoplasmic reticulum stress
  • oxidative stress